All the distributions, apart from Fedora Design Suite, have the JACK system installed and configured, which is what A most Linux audio apps expect. Of those four, only Fedora Jam lacked the customisation of adding the user to the ‘audio’ group, something that makes audio apps run more smoothly. A slight wrinkle affecting them all is that their base distros now run on PipeWire, a new audio system. This means you may still have to tweak your system for best performance.
AV Linux uses the Liquorix Kernel (https://liquorix.net), a special build of the Linux kernel that is tuned for multimedia work in areas such as swap usage, process scheduling and CPU frequency. The compromise is that it gives lower throughput in some situations and consumes more power, something to bear in mind if using it on a laptop. Having a non-standard kernel could throw up some unusual problems in rare cases, but overall, having Liquorix Kernel installed is a boon for multimedia work.