As long as you’re already familiar with using Big Sur, with its new human interface, you’ll notice relatively little change in design, layout or controls in Monterey. If you’re coming from an older version of macOS, you may be shocked to discover what’s happened, particularly in the top of windows. Small windows with lots of tools can make it hard to find anywhere that’s safe to use to drag the window around, but you’ll develop that skill in time.
Time Machine will also try to keep backups of what’s in your iCloud Drive.