Frank Zappa’s guitars became test beds for his mad scientist modifications, and his son Dweezil has explained his secrets. Frank’s main pursuit was controllable feedback, and he fitted his guitars with active EQ circuits offering a huge 18dB boost. At each venue he’d find the feedback resonant frequency, then boost it. You could try a parametric EQ for similar results. The Baby Snakes SG was Zappa’s main 70s guitar, with details such as stylish inlays and 23-fret range proving its non-Gibson origins.